Setting up email is pretty much one of the first outward facing things that a startup does. You need to own your company identity, and folks need to associate you, your product, your everything, with that identity. This often happens first via email.
So let’s say your name is Bob Fundergrass, you’re a founder, and your startup’s domain is toejamsoup.com. If I can’t email you at email@example.com, you’re an idiot and you are doing it wrong. I don’t care if you really use firstname.lastname@example.org, or some other variation, but your first name, what people actually call you, better work. If it doesn’t, you’re an idiot.
Please don’t make this mistake. You’re a founder, claim that first name and own it. Sure, maybe down the road you’ll have 30,000 employees and need a really stodgy, strict format, but right now, you need to make it as easy as possible for everyone and anyone to email you. Your first name @ your domain is the easiest way to do this.
You have enough things stacked against you already, please don’t add bounced or black-holed emails to the list.
PS: An easy way to do this if you use Google Docs is to set up a Group and name it and set the Group email address as your “easy” address. Then just set your main account as the owner and select “Also allow anyone on the Internet to post messages.” Bingo. You’ll capture those emails and be able to reply from your preferred address.